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KMID : 0043320080310050573
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Archives of Pharmacal Research
2008 Volume.31 No. 5 p.573 ~ p.578
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Heterocyclic Compounds from Chrysanthemum coronarium L. and Their Inhibitory Activity on hACAT-1, hACAT-2, and LDL-Oxidation
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Song Myoung-Chong
Yang Hye-Joung
Jeong Tae-Sook
Kim Kyong-Tai
Baek Nam-In
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Abstract
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The aerial parts of Chrysanthemum coronarium L. were extracted with MeOH, and the concentrated extract was partitioned using EtOAc, n-BuOH, and , successively. Repeated column chromatography of the EtOAc and n-BuOH fractions gave a new heterocycle, 5,5’-dibuthoxy-2,2’-bifuran (1) along with five known compounds: methyl trans-ferulate (2), prunasin (3), sambunigrin (4), pterolactam (5), and adenosine (6), which were identified by several spectroscopic methods including NMR and MS. This paper is the first report on the isolation of these compounds from C. coronarium L. The values of compound 1 for human Acyl-CoA:cholesterol acyltransferase (hACAT)-1 and hACAT-2 were 0.16 mM and 0.19 mM, respectively. Compound 2 inhibited low-density lipoprotein (LDL) oxidation with an value of .
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KEYWORD
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Chrysathemum coronarium L, 5, 5’-Dibuthoxy-2, 2’-bifuran, Methyl trans-ferulate, Prunasin, Sambunigrin, Pterolactam, Adenosine, hACAT, LDL-Oxidation
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